In cannabinoid-based therapy, evidence is part of development - not an after-the-fact proof.
That is why Medi First R&D works with standardized evidence pathways to bring target profiles (TPP), formulation, and clinical application together within a consistent criteria logic.
Request a methodology briefing
Note: Provision after qualification, possibly NDA-based.
Methodological validation: from the clinical target profile to robust evidence.
The logic of reverse engineering
We start with the clinical requirement. Via a Target Product Profile (TPP), parameters for efficacy, tolerability, dosability, and use are defined - before formulation and prototyping begin. This keeps development traceable, comparable, and consistently oriented toward real clinical endpoints.
The evidence pipeline: a multimodal approach
We generate evidence along a structured pipeline, tailored to the question and development phase:
01 Preclinical validation
Characterization of biochemical profiles and suitable preclinical models to test defined hypotheses.
02 Observational research / Real-World Data (RWD) & Real-World Evidence (RWE)
Analysis of anonymized care data and outcomes to assess tolerability, use, and adherence under real-world conditions.
03 Clinical protocolization (e.g., non-interventional studies, indication-specific protocols)
Transfer of insights into standardized application and observation protocols that support clinical decision-making processes.
Our basis for iterative optimization in the evidence loop: evidence generation (preclinical · observational · clinical).
Integrated data loop through vertical integration.
A key feature of Medi First R&D is the direct connection to the group’s own care network. The closed-loop approach makes it possible to feed anonymized data from clinical practice back into research in a structured way.
Data integrity as an ethical and professional obligation.
Our evidence system operates under strict adherence to international standards. All data collection is GDPR-compliant and anonymized; our processes are documented and quality-assured. The goal is evidence that is scientifically traceable, regulatorily compatible, and implementable within care processes.
Collaboration
We support hospitals, universities, and industry partners in planning and executing evidence-based projects - from scoping and protocol design to analysis.
Inquire about collaboration
Note: Information on this website is intended for professional and collaboration partners. It does not constitute medical advice in any way.
